Curriculum Vitae

Also available to download here. Last updated April 2025.

Experience

Study Director | Panome Bio | St. Louis, MO | April 2025 - Present

• Oversee the design, execution, and delivery of multi-omic studies, ensuring scientific rigor and client satisfaction from project initiation through final reporting.
• Serve as a topic expert supporting the sales team during client meetings, translating complex multi-omics concepts into clear value propositions.
• Lead development of analytical pipelines and new service offerings, expanding the company’s technical capabilities and portfolio.

Multi-Omic Analyst | Panome Bio | St. Louis, MO | May 2024 - April 2025

• Analyzed and interpreted multi-omics data (metabolomics, proteomics, transcriptomics, etc.) to deliver actionable insights for client projects, driving informed decision-making.
• Provided expert guidance on microbiome and metabolome work to business development teams, supporting client acquisition and engagement through presentations, consultations, and technical expertise.
• Spearheaded the development and successful launch of a novel gut microbiome function assay within the first 8 months of employment, including leading webinars and presenting research findings at conferences.

Graduate Research Assistant | Michigan State University | East Lansing, MI | Aug 2019 - Apr 2024

Quinn Lab - Departments of Microbiology, Genetics, & Immunology and Biochemistry & Molecular Biology
My primary research project focused on determining mechanisms behind bile acid conjugation by intestinal microorganisms and investigated consequences of this aspect of microbial bile acid metabolism on the host.

• Data steward to a 1,400 sample mother-infant cohort, with paired microbiome and metabolome datasets.
• Performed enzyme kinetic experiments to characterize bile acid conjugation by bile salt hydrolase.
• Analyzed and identified key changes in the metabolome and microbiome across a variety of clinical, environmental, and in vitro microbiological sample types.

Visiting Graduate Researcher | Wellcome Sanger Institute | Cambridge, England, UK | Feb 2023 - Mar 2023

Lawley Lab - Host-Microbiota Interactions

• Taught untargeted mass spectrometry experimental design, sample preparation, and analysis techniques.
• Developed skills involved in genomic, metagenomic, and phylogenetic analyses leveraging high-performance computation.

Undergraduate Research Assistant | The Ohio State University | Columbus, OH | Oct 2018 - Jun 2019

Stoodley Lab - Department of Microbial Infection and Immunology

• Developed high-throughput methods to quantify biofilm-independent Staphylococcus aureus aggregation using 96-well plate imaging.
• Determined relative contribution of synovial fluid components in cell aggregation within the context of periprosthetic joint infection.

Undergraduate Research Assistant | The Ohio State University | Columbus, OH | Feb 2017 - Aug 2018

Roy Lab - Center for Minimally Invasive Surgery, Department of Surgery

• Assisted with development and data collection of a maxillofacial burn wound model.
• Investigated the roles of host and bacterial extracellular vesicles in infection.

Education

Ph.D., Microbiology and Molecular Genetics

Michigan State University | East Lansing, MI | Aug 2019 - Apr 2024

Dissertation: Elucidating the mechanisms behind microbial bile acid conjugation and its impacts on host microbiota and physiology.

B.S. Microbiology, cum laude

The Ohio State University | Columbus, OH | Aug 2015 - May 2019

Thesis: Determining the impact of host-synovial fluid factors on Staphylococcus aureus aggregation.

Publications

^‡Indicates equal authorship contribution. For the most up-to-date list, please check my Google Scholar or ORCID.

Cornelius P, Mayes BA, Dannenberg AJ, Dufour PJ, Little S, Guzior DV, Petersen JS, Shanahan JM, Carver BJ. 2026. Evexomostat (SDX-7320), a methionine aminopeptidase type 2 inhibitor, stimulates weight loss and inhibits obesity-accelerated tumor growth. Front. Oncol. 16:1751681. doi: 10.3389/fonc.2026.1751681

Dean AE, Guzior DV, Quinn RA, Gaulke CA, Anakk S. 2025. Serum cholic acid and cecal Faecalibaculum increase in a male-specific manner in a murine hepatocellular carcinoma model. J. Lipid Res. 67(1):100954. doi: 10.1016/j.jlr.2025.100954

González CT, Martin C, Crane M, Gutierrez K, Thomas J, Remisoski L, Okros M, Fu Y, Guzior DV, Finkhouse D, Bridges C, Mielke J, Querido G, Padillo L, Girgis R, McClelland M, Conrad D, Li X, Quinn RA. 2025. Microenvironmental effects of a non-antibiotic therapy for a chronic polymicrobial infection alter microbial physiology, competition, and virulence. ISME J 19:wraf125. doi: 10.1093/ismejo/wraf125

McGilvrey MI, Fortier B, Cooke D, Mahdi MA, Tero B, Potts CM, Kaija A, Ryzhova L, Cora C, Richardson A, Guzior DV, Pinz I, Vary C, Koza RA, Ables G, Liaw L. 2025. Short-term dietary methionine restriction with high fat diet counteracts metabolic dysfunction in male mice. Physiol Rep 13:e70405. doi: 10.14814/phy2.70405

Fu Y, Guzior DV, Okros M, Bridges C, Rosset SL, González CT, Martin C, Karunarathne H, Watson VE, Quinn RA. 2025. Balance between bile acid conjugation and hydrolysis activity can alter outcomes of gut inflammation. Nat Commun 16:3434. doi: 10.1038/s41467-025-58649-x

Won TH, Arifuzzaman M, Parkhurst CN, Miranda IC, Zhang B, Hu E, Kashyap S, Letourneau J, Jin WB, Fu Y, Guzior DV, Quinn RA, Guo CJ, David LA, Artis D, Schroeder FC. 2025. Host metabolism balances microbial regulation of bile acid signalling. Nature 638(8049):216–224. doi: 10.1038/s41586-024-08379-9

Wu H^‡, Guzior DV^‡, Martin C, Neugebauer KA, Rzepka MM, Lumeng JC, Quinn RA, de los Campos G. 2024. Longitudinal analyses of infants’ microbiome and metabolome reveal microbes and metabolites with seemingly coordinated dynamics. Commun. Biol. 7:1506. doi: 10.1038/s42003-024-07015-6

Hansen ZA, Schilmiller AL, Guzior DV, Rudrik JT, Quinn RA, Vasco KA, Manning SD. 2024. Shifts in the functional capacity and metabolite composition of the gut microbiome during recovery from enteric infection. Front. Cell. Infect. Microbiol. 14:1359576. doi: 10.3389/fcimb.2024.1359576

Guzior DV, Okros M, Shivel M, Armwald B, Bridges C, Fu Y, Martin C, Schilmiller AL, Miller WM, Ziegler KM, Sims MD, Maddens ME, Graham SF, Hausinger RP, Quinn RA. 2024. Bile salt hydrolase/acyltransferase activity shapes bile acid diversity. Nature 626:852–858. doi: 10.1038/s41586-024-07017-8

Chargo NJ, Neugebauer K, Guzior DV, Quinn RA, Parameswaran N, McCabe LR. 2024. Glucocorticoid-induced osteoporosis is prevented by dietary prune in female mice. Front. Cell. Dev. Biol. 11:1324649. doi: 10.3389/fcell.2023.1324649

Martin C, Guzior DV, Gonzalez CT, Okros M, Mielke J, Padillo L, Thomas R, McClelland M, Conrad D, Widder S, Quinn RA. 2023. Longitudinal microbial and molecular dynamics in the cystic fibrosis lung after Elexacaftor-Tezacaftor-Ivacaftor therapy. Respir. Res. 24:317. doi: 10.1186/s12931-023-02630-z

Quinn RA, Martin C, Guzior DV. 2023. A multi-omic trip through the human gut. Nat. Metab. 5:720–721. doi: 10.1038/s42255-023-00773-3

Neugebauer KA, Okros M, Guzior DV, Feiner J, Chargo NJ, Rzepka M, Schilmiller AL, O’Reilly S, Jones AD, Watson VE, Luyendyk JP, McCabe LR, Quinn RA. 2022. Baat gene knockout alters post-natal development, the gut microbiome, and reveals unusual bile acid conjugates in mice. J. Lipid Res. 63:100297. doi: 10.1016/j.jlr.2022.100297

Ghuneim L-AJ, Raghuvanshi R, Neugebauer KA, Guzior DV, Martin C, Schena B, Feiner JM, Castillo-Bahena A, Mielke J, McClelland M, Conrad D, Klapper I, Zhang T, Quinn RA. 2022. Complex and unexpected outcomes of antibiotic therapy against a polymicrobial infection. ISME J 16:2065–2075. doi: 10.1038/s41396-022-01252-5

Sosinski LM, Martin C, Neugebauer KA, Ghuneim L-AJ, Guzior DV, Castillo-Bahena A, Mielke J, Thomas R, McClelland M, Conrad D, Quinn RA. 2022. A restructuring of microbiome niche space is associated with Elexacaftor-Tezacaftor-Ivacaftor therapy in the cystic fibrosis lung. J. Cyst. Fibros. 21:996–1005. doi: 10.1016/j.jcf.2021.11.003

Wurster JI, Peterson RL, Brown CE, Penumutchu S, Guzior DV, Neugebauer KA, Sano WH, Sebastian MM, Quinn RA, Belenky P. 2021. Streptozotocin-induced hyperglycemia alters the cecal metabolome and exacerbates antibiotic-induced dysbiosis. Cell Rep 37:110113. doi: 10.1016/j.celrep.2021.110113

Guzior DV, Quinn RA. 2021. Review: microbial transformations of human bile acids. Microbiome 9:140. doi: 10.1186/s40168-021-01101-1

Pestrak MJ, Gupta TT, Dusane DH, Guzior DV, Staats A, Harro J, Horswill A, Stoodley P. 2020. Investigation of synovial fluid induced Staphylococcus aureus aggregate development and its impact on surface attachment and biofilm formation. PLoS ONE 15:e0231791. doi: 10.1371/journal.pone.0231791

Conference Presentations

Talks

Guzior DV, Wu H, Martin C, Rzepka M, Neugebauer KA, Lumeng J, de los Campos G, Quinn RA. Developmental dynamics of the infant fecal metabolome.
MANA 2023 | October 2023 | Columbia, MO

Guzior DV, Quinn RA. Bile salt hydrolase aminoacyltransferase activity from gut anaerobes expands the human bile acid pool.
Anaerobe 2023 | July 2023 | Cardiff, Wales, UK | Awarded Best Offered Talk

Guzior DV, Quinn RA. Reversing Dogma: Bile Salt Hydrolase.
Anaerobe Congress | July 2022 | Seattle, WA

Awards & Fellowships

Dissertation Completion Fellowship, The Graduate School, Michigan State University, 2024

Graduate School Travel Fellowship, The Graduate School, Michigan State University, 2023

Ralph Evans Award, Department of Microbiology, Genetics, & Immunology, Michigan State University, 2023

Outstanding Scholar Fellowship, College of Natural Science, Michigan State University, 2022-2023

Philipp and Vera Gerhardt Award, Department of Microbiology, Genetics, & Immunology, Michigan State University, 2021

Professional Memberships

Metabolomics Association of North America

American Society for Microbiology

Microbiology Society

Anaerobe Society of the Americas

Service & Leadership

Annual Fundraiser and Shavee (over $8,000 raised), St. Baldrick’s Foundation, 2015-Present

Graduate Student Mentor, Graduate Recruitment Initiative Team, Michigan State University, 2022-2024

Graduate Committee Representative, Department of Microbiology, Genetics, & Immunology, Michigan State University, 2022-2024

Volunteer, Science Debate - MSU Chapter, 2020

Donor, Be The Match, 2020

Skills & Expertise

Laboratory: targeted and untargeted metabolomics, liquid chromatography-tandem mass spectrometry, microbiome analysis, 16S amplicon sequencing, bacteriology, aerobic and anaerobic, biofilm culture, primer design, polymerase chain reaction (PCR), Gibson assembly, plasmid assembly and transformation, tissue sectioning, frozen or wax-embedded, immunohistochemistry, confocal and light microscopy, ZEN slide imaging (Zeiss Axio Scan Z1), wound harmonic ultrasound imaging, laser speckle microperfusion imaging, general photography, digital planimetry, troubleshooting, problem-solving

Computation and Statistics: high-performance computing, machine learning, hierarchical cluster analysis, statistics best practices, data visualization

Software: R, Python, QIIME 2, XCaliber, MZmine, Cytoscape, Adobe Illustrator, Microsoft 365

Communication: technical writing, peer-reviewed publication, public speaking, teaching, mentorship, multi-national collaboration